Biomarker Helps Identify Mental Illness in Women By Rick Nauert PhD

The discovery of the inactive “X” traits opens a great field of possibility in treating a wide variety of illnesses.

The connection between an inactive X trait (ie. G6PD def) and development of neurological disorders (MS in this case) was one topic in my PhD research. This tendency has been known for more than a decade. I am happy to see more acknowledgement that “inheritance” is not as simple as Mendel’s peas!

The press release begins here:

In a new study, researchers have identified a biomarker that could be an indicator of mental illness in females.

As background information, researchers at University of California, San Diego School of Medicine explain that psychiatric disorders can be difficult to diagnose because clinicians must rely upon interpreted clues.

The indications of a mental illness often include a patient’s behaviors and feelings. Identification of a mental illness by matching behaviors to genetic predispositions would facilitate a timely diagnosis, and aid intervention and research.

In the study, University of California, San Diego investigators report that for the first time, they have identified a biological marker: the over-production of specific genes that could be a diagnostic indicator of mental illness in female psychiatric patients.

The study was published this week in the journal EBioMedicine.

Researchers discovered the gene XIST — which is responsible for inactivating one of the two copies of the X chromosome in cells that store genetic material — works overtime in female patients with some forms of mental illnesses.

Investigators found that the illnesses include bipolar disorder, major depression, and schizophrenia.

The study suggests that over-production of XIST and genes from the inactive X chromosome are common denominators in the development of psychiatric disorders in patients with rare chromosome disorders, such as Klinefelter syndrome and Triple X syndrome, and in the general population of female psychiatric patients.

“There has been an utmost urgency to identify biomarkers for mental illness that could significantly impact research and drug development,” said Xianjin Zhou, Ph.D. , assistant professor in the Department of Psychiatry at University of California, San Diego School of Medicine and lead author.

The study was conducted on 60 lymphoblastoid cell lines from female patients, most of whom had a family history of mental illness. Approximately 50 percent of the female patients exhibited abnormally higher levels of XIST and other genes related to the X chromosome.

Zhou and his team said reversing the abnormal activity of the inactive X chromosome in patients suffering from mental illness may offer a potential new strategy for treating psychiatric disorders.

“Our results indicate that a large subpopulation of female psychiatric patients from the general population may have abnormal function of the inactive X chromosome,” said Zhou.

“These results are powerful in that early diagnosis of mental illness could possibly happen with a simple blood test, leading to better interventions, therapy, and treatment options.”

Source: University of California, San Diego/EurekAlert!


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